Higher Accuracy and Efficiency in Filtration

Filtration is a critical step in the purification of biopharmaceuticals such as proteins, antibodies, and vaccines. It describes the separation of undesired particles from biological materials by using different types of purification technologies such as alternating tangential flow filtration (ATF), tangential flow filtration (TFF), or ultrafiltration (UF) to obtain contamination-free products.

The performance characteristics of the filter, including flow rate and capacity, play an important role in the filtration process. It is important to optimize the flow rate to ensure efficient processing without affecting filtration performance. Non-contact clamp-on flow meters can be used for both real-time flow rate control and volume control to ensure consistent filtration performance.

For consistently high performance, filters must be cleaned regularly and wetted before use. Proper cleaning removes residual contaminants, while effective wetting ensures optimal filter performance and consistent flow rates. 

Non-contact ultrasonic flow meters enable accurate, real-time flow monitoring without disrupting sterile environments or requiring system downtime. Their non-invasive clamp-on design minimizes contamination risk and maintenance requirements, supporting more reliable and efficient filtration operations.

Enhanced Filter Protection

The presence of air bubbles can have a significant impact on the efficiency of the filtration cassettes and therefore negatively affect product quality and yield. Early detection of air bubbles prevents uneven pressure distribution, ensuring consistent and reliable flow and filtration performance.

The SONOCHECK ABD06 ultrasonic air bubble detectors reliably detect air bubbles without having contact with the medium. Thanks to the transmission principle, the sensors measure through the wall of the tubing. They are free of wear and tear.

Filtration is important in the purification of biopharmaceuticals, including proteins, antibodies, and vaccines. Optimizing the flow rate and capacity is essential for efficient processing without compromising performance.

Non-contact clamp-on flow meters enable real-time monitoring without disrupting the process. The early detection of air bubbles is crucial to prevent pressure imbalances, ensuring reliable filtration.

• Enhanced Accuracy and Repeatability:
  Non-contact flow meters provide real-time flow rate measurements with an accuracy of 1%, ensuring consistent filtration performance to meet high PAT requirements.
• Automation & Process Control:
  Various sensor performance data can be used in AI models to analyse filter conditions or flow anomalies.
• Constant High Product Quality:
  Ultrasonic air bubble detectors signal the presence of air bubbles, preventing sudden pressure drops in the process and potential harm to product quality.
• Minimizing Downtime:
  Clamp-on flow meters can be installed quickly without disrupting the process. These sensors are cost-efficient and free of wear and tear.

Benefit from our flow meters and air bubble detectors!

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